Biological fermentation Ha /hyaluronic Acid Sodium Hyaluronate Powder Pharmaceutical Grade medicine grade acido hialuronico

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  • 1 - 4 Kilograms
    $18,000.00
  • 5 - 9 Kilograms
    $16,500.00
  • >=10 Kilograms
    $15,000.00
Lead Time:
Quantity(Kilograms) 1 - 10 >10
Est. Time(days) 3 Negotiable
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Overview
Quick Details
CAS No.:
9004-61-9
Other Names:
Sodium Hyaluronate
MF:
(C14H20NO11Na)n
EINECS No.:
232-678-0
Place of Origin:
Shandong, China
Type:
pharmaceutical grade hyaluronic acid raw material powder
Grade Standard:
Medicine Grade
Usage:
Animal Pharmaceuticals
Brand Name:
Orientalgreenbiology
Model Number:
001
Purity:
99.9%min
Grade Standard::
Medicine Grade
grade::
injection grade
color::
white powder
Solubility:::
Soluble in water
Supply Type:::
OEM/ODM
Molecular Weight:::
50000--2000000DA
Shelf life:
2 Years
MOQ:
1 KG
Keyword:
hyaluronic acid powder
Brand:
DFLK
Supply Ability
Supply Ability:
10 Kilogram/Kilograms per Month Sodium Hyaluronate Powder
Packaging & Delivery
Packaging Details
1kg with plastic container inside/Aluminum foil bag inside
25kg with double plastic container inside/ Fiber drum outsinde\
Or at your request
Port
Shanghai;Qingdao Shenzhen
Lead Time :
Quantity(Kilograms) 1 - 10 >10
Est. Time(days) 3 To be negotiated
Product Description

Sodium hyaluronate is the sodium salt of hyaluronic acid. It is a glycosaminoglycan and long-chain polymer of disaccharide units of Na-glucuronate-N-acetylglucosamine. It can bind to specific receptors for which it has a high affinity.
The polyanionic form, commonly referred to as hyaluronan, is a visco-elastic polymer found in the aqueous and vitreous humour of the eye and in the fluid of articulating joints.

Natural occurrence

Sodium hyaluronate is distributed widely in the extracellular matrix of mammalian connective, epithelial, and neural tissues, as well as the corneal endothelium.

Mechanism of action

Sodium hyaluronate functions as a tissue lubricant and is thought to play an important role in modulating the interactions between adjacent tissues. It forms a viscoelastic solution in water. Mechanical protection for tissues (iris, retina) and cell layers (corneal, endothelium, and epithelium) are provided by the high viscosity of the solution. Elasticity of the solution assists in absorbing mechanical stress and providing a protective buffer for tissues. In facilitating wound healing, it is thought that it acts as a protective transport vehicle, taking peptide growth factors and other structural proteins to a site of action. It is then enzymatically degraded and active proteins are released to promote tissue repair.

                                                                   (Injection) Hyaluronic Acid

Source: Fermented                                                                                                             Manufacture Date:June.09th, 2018

Grade:Injection Grade                                                                                                         Batch No.: GL-180609

Test Items
Standard
Result
Appearance
White powder
White powder
Hyaluronic Acid
95.0%--105.0%
99.9%
Molecular weight
(1.5---2.0) X 106
1.7 X 106
PH
5.0-7.5
6.8
Chlorides
≤0.5
0.25
600nm.The optical absorption 1-300
<0.01
Complies
260 nm optical absorption 1-300
<0.5
Complies
Loss on drying
≤10%
8.9%
Protein
≤0.05%
0.03%
Iron
≤10ppm
Complies
Bacterial counts
≤10cfu/g
Complies
Protein
≤0.05%
0.03%
Iron
≤10ppm
Complies
Bacterial counts
≤10cfu/g
Complies
Endotoxin
≤0.05eu/mg
0.03eu/mg
Sterile Test
Complies
Complies
Shelf Life
Two Years
Detailed Images

Medical uses

Intra-articular injection

It is used to treat knee pain in patients with osteoarthritis who have not received relief from other treatments. It is injected into the joint capsule, to act as both a shock absorber and a lubricant for the joint. Thus sodium hyaluronate is used as a viscosupplement, administered through a series of injections into the knee, increasing the viscosity of the synovial fluid, which helps lubricate, cushion and reduce pain in the joint. It is generally used as a last resort before surgery and provides symptomatic relief, by recovering the viscoelasticity of the articular fluid, and by stimulating new production from synovial fluid. Use of sodium hyaluronate may reduce the need for joint replacement. Injections appear to increase in effectiveness over the course of four weeks, reaching a peak at eight weeks and retaining some effectiveness at six months, with greater benefit for osteoarthritis than oral analgesics. It may also be effective when used with the ankle joint.

Intraocular viscoelastic injection

It is used as an aid in ophthalmic surgery acting as aqueous and vitreous humor, e.g. in cataract extraction (intra- and extracapsular), intraocular lens implantation, corneal transplant, glaucoma filtration, and retina attachment surgery and in the treatment of dry eyes. In surgical procedures in the anterior segment of eyeball, instillation of sodium hyaluronate its viscoelasticity enables maintenance of a deep chamber during surgical manipulation since the solution does not flow out of the open anterior chamber, allowing for efficient manipulation with less trauma to the corneal endothelium and other surrounding tissues. Its viscoelasticity also helps to push back the vitreous face and prevent formation of a postoperative flat chamber. In posterior segment surgery, sodium hyaluronate serves as a surgical aid to gently separate, maneuver, and hold tissues. It creates a clear field of vision, facilitating intra-operative and post-operative inspection of the retina and photocoagulation.

Skin injections in plastic surgery

Sodium hyaluronate is injected to reduce wrinkles on the face. As of 2017, the FDA had approved 13 hyaluronate preparations as so called dermal fillers. They are also used as a filler of lips or in other parts of the body, though not FDA approved. The filling effect is temporary and lasts for about six months or longer in most people.

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